peptide that fights disease.
by *Will Brink
(from the October
2000 issue of Life Extension)
readers of the LIFE EXTENSION MAGAZINE are aware, whey protein
appears to function as a natural food against cancer, HIV, overtraining
syndrome in athletes and a host of pathologies. In Particular,
whey's efffects on glutathione levels and Immunity are
well documented in many animal studies with a growing number of
human studies confirming the results with animals.
Whey is one of two major proteins
found in milk, the other being casein.When we talk about whey
we are actually referring to a complex protein made up of many
smaller protein subfractions (peptides), including beta-lactoglobulin,
alpha-lactalbumin, immunoglobulins, glycomacropeptides, bovine
serum albumin (BSA), and minor peptides such as lactoperoxidases,
lysozyme and lactoferrin. Each of the subfractions found in whey
has its own unique biological properties.
Up until quite
recently, separating these subfractions on a large scale was either
impossible or prohibitively expensive. Modern filtering technology
has improved dramatically in the past few years allowing a handful
of companies to seperate some of the highly bioactive peptides
from whey, such as LACTOFERRIN. Many of these subfractions are
only found in very minute amounts in cows milk, normally at less
than 1%. For example, lactoferrin makes up approximately 0.5%
- 1% or less of whey protein derived from cows milk, where as
human mothers milk will contain up to 15% lactoferrin.
appears to be the subfraction of whey with documented anti-viral,
anti-microbial, anti-cancer and immune modulating/enhancing effects.
There is little doubt that lactoferrin could become the natural
compound of choice in the treatment and prevention of a host of
human ailments. To follow is a summary of what lactoferrin might
have to offer.
A minor fraction
of whey, lactoferrin appears to have a wide variety of uses in
biological systems and is considered a first line immune defense
in the human body.
appears to be particularly important in the health and function
of the intestinal tract and has been found to greatly reduce systemic
and intestinal inflammation in such conditions as inflamatory
bowel disease and others. The gastrointestinal tract must be viewed
as an ecologic system in which a balance between both good and
bad bacterial flora(micro flora) exists. An overgrowth of bad
bacteria in the intestinal tract is known to casue a wide range
of sever problems that cause a myraid of pro-inflammatory mediators
to be released, causing disruptions throughout the entire body.
When fed to
adult animals and human infants, lactoferrin showed a dramatic
increase in good microflora,such as bifidus,and a decrease in
bad bacteria, such as E.coli, streptococcus,clostridium and others.
The result was desirable intestinal flora, which is known to be
essential for optimal health, immunity and resistance to disease.
has been found to both directly and indirectly inhibit several
viruses that cause disease in humans. It directly inhibits viruses
by binding to viral receptor sites, thus preventing the virus
from infecting healthy cells.
to note that there is a systemic deficiency of lactoferrin in
people with HIV infection.Lactoferrin was also found to have a
"potent" anti-viral effects against the replication
of both human HIV and cytomegalovirus (CMV) virus in several in
vitro studies with no cytopathic effects on healthy cells.
of lactoferrin in viral infections warrants a great deal of further
research and use by clinicians. There is little doubt that lactoferrin
is a key molecule for the body and the immune system in the fight
against viruses and other microbes, and could be an effective
supplement for people with viral infections.
of the most promising uses for lactoferrin may be in its potential
as a nontoxic adjuvant cancer treatment agent. Extensive in-vitro(test
tube) and in-vivo research with animals has shown lactoferrin
to be a powerful anti-cancer agent.
using both rats and mice exposed to a toxic chemical (zaoxymethane)
known to cause tumors throughout the gastrointestinal tract, administered
concomitanlty with lactoferrin, showed a large reduction in intestinal
polyp development. Just as important, there were no toxic effects
to intestinal epithelial tissues.
found the addition of lactoferrin to cancer prone mice subjected
to cancer causing chemicals reduced the number of tumors and suppressed
angiogenesis (the production of new blood vessels), which tumors
need to survive. This study also found lactoferrin "significantly
inhibited" liver and lung metastasis of cancer cells in these
study found lactoferrin to be very effective at suppressing the
growth of human pancreatic cancer cells. So much so the researchers
concluded that lactoferrin"...might become one of the new
drugs of choice for the adjuvant therapy against pancreatic cancer."
One study that examined lactoferrin's effects on chemically induced
colon cancer found that "no effects indicative of toxicity
were noted(from the use of lactoferrin), but significant reductions
in both incidence and number of adenocarcinomas (tumors) of the
large intestine were observed in almost all treatments.
best known role is as an iron binding protein. It's referred to
as hololactoferrin in its iron bound form and apolacroferrin in
its iron depleted form.Directly related to lactoferrin's previously
mentioned ability to suppress certain health degrading bacteria
in the intestine, lactoferrin is a powerful anti-microbial that
inhibits a wide range of pathogenic bacteria and other microbes
AS AN ANTIOXIDANT
is an antioxidant that scavenges free iron, helping to prevent
uncontrolled iron based free radical reactions, thus protecting
certain cells from peroxidation. Though lactoferrin is both an
iron scavenger and donor (depending on the cellular environment),
it has been found to scavenge or donate iron at the appropriate
times when the body is in need of the reaction.
suggest lactoferrin reduces oxidative stress. Diseases such as
cancer, heart diseases, and AIDS are all closely related to oxidative
stress either as a causative factor or as a factor in progression
of the disease.
One study that
examined the role of WHEY PROTEINS, multifermented whey proteins
and lactoferrin in oxidative stress made the bold statement,"We
can conclude that whey protein, lactoferrrin and multifermented
whey are good candidates as dietary inhibitors of oxidative stress
and should be considered as potential medicinal foods in various
pathologies as HIV infections and cancer."
There is little
doubt that lactoferrin is a major find and a potential breakthrough
as a natural nontoxic treatment in an array of human ailments.
*William D. Brink is a well known medical,fitness
and health writer for a variety of publications. He graduated
from Harvard University with a degree in the natural sciences,
and is a regular guest on national radio shows and a speaker at
various conventions around the U.S.
report from the
Cancer Center Research Institute in Tokyo, Japan
that whey protein, particularly its major component bovine lactoferrin
(bLF), may inhibit colon cancer. Results from earlier research
they had conducted in a rat model, showed a lower incidence and
number of adenocardnomas in bLF-fed animals. After administering
various doses of bLF for 36 weeks, in conjunction with three weekly
injections of a carcinogen, results showed that the incidence
of adenocardnomas in rats receiving 2% and 0.2% blf were 15% and
25%, respectively. In contrast, the control rats had an incidence
rate of 57.5 %. These results basically show bLF's ability to
reduce colon cancer by 50%
Calcium has been receiving attention after showing
the potential to cut colon cancer risk in recent human trials.
It's believed to exert its anti-carcinogenic activity possibly
by helping to bind both fatty acid and bile acid in the colon
and keeping them from interacting with and irritating the colon
lining. A recent study that tracked 70 patients at risk for colon
cancer for a year had half of its participants consume their normal
diet, while asking the other half to increase their calcium intake
from low-fat foods to about 1500mg per day. The investigators
report significant improvements in the risk biomarkers for men
who followed the high-calcium diet.
& Best WheyMilk HAS
30 % WHEY PROTEIN and 35% RDA OF CALCIUM IN EVERY 8 OZ. GLASS!!
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